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KMID : 0359920100290010125
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Korean Journal of Nephrology
2010 Volume.29 No. 1 p.125 ~ p.130
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Development of IgA Nephropathy after Clinical Remission of Dense Deposit Disease
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Kim Min-Ju
Lim Beom-Jin
Shin Jae-Il
Lee Jae-Seung
Lee Yoon-Hee
Joh Ken-suke
Kim Pyung-Kil
Jeong Hyeon-Joo
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Abstract
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Dense deposit disease (DDD) is a rare primary glomerulonephritis characterized by continuous bandlike intramembranous dense deposits detectable on electron microscopy. We describe a case of DDD with sequential mesangial proliferative glomerulonephritis, membranoproliferative glomerulonephritis, minor glomerular alterations, and a second round of mesangial proliferative glomerulonephritis during a 13-year period. Electron dense deposits were typical of DDD in the first and second biopsies taken one year apart. However, deposits dissolved and the glomerular cellularity and basement membrane normalized with clinical remission, which was achieved by a course of immunosuppressive therapy lasting seven years. The fourth biopsy was performed due to recurrence of microscopic hematuria and showed predominant mesangial IgA deposits without glomerular capillary alteration, which was interpreted as development of IgA nephropathy after remission of DDD or coexistence with nearly healed DDD in this patient.
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KEYWORD
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Hypocomplementemic glomerulonephritis, Dense deposit disease, IgA nephropathy
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